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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PRKCA
All Species:
37.88
Human Site:
Y557
Identified Species:
75.76
UniProt:
P17252
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P17252
NP_002728.1
672
76764
Y557
I
M
E
H
N
V
S
Y
P
K
S
L
S
K
E
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001096447
673
76980
Y560
I
M
E
H
N
V
A
Y
P
K
S
M
S
K
E
Dog
Lupus familis
XP_548026
590
67545
F515
D
V
R
E
H
A
F
F
R
R
I
D
W
E
K
Cat
Felis silvestris
Mouse
Mus musculus
P20444
672
76833
Y557
I
M
E
H
N
V
S
Y
P
K
S
L
S
K
E
Rat
Rattus norvegicus
P05696
672
76773
Y557
I
M
E
H
N
V
S
Y
P
K
S
L
S
K
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510097
675
76844
Y560
I
M
E
H
N
V
S
Y
P
K
S
L
S
K
E
Chicken
Gallus gallus
NP_001012822
674
76827
Y559
I
M
E
H
N
V
S
Y
P
K
S
L
S
K
E
Frog
Xenopus laevis
Q7LZQ8
671
76506
Y557
I
M
E
H
N
V
A
Y
P
K
S
M
S
K
E
Zebra Danio
Brachydanio rerio
Q90XF2
588
67303
H511
G
F
A
D
I
M
A
H
P
F
F
R
N
V
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P05130
679
77676
Y568
I
T
D
H
N
V
S
Y
P
K
S
L
S
K
E
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P90980
682
77982
Y566
I
T
E
H
N
V
S
Y
P
K
S
L
S
K
E
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
P87253
1142
127954
Y1036
I
L
A
D
E
P
L
Y
P
I
H
M
P
R
D
Conservation
Percent
Protein Identity:
100
N.A.
80.2
86.7
N.A.
98.3
99.4
N.A.
97.1
93.9
78.4
34.6
N.A.
67.1
N.A.
66.4
N.A.
Protein Similarity:
100
N.A.
88.8
87.1
N.A.
98.8
99.6
N.A.
98.2
96.7
87
52.2
N.A.
80.7
N.A.
79.7
N.A.
P-Site Identity:
100
N.A.
86.6
0
N.A.
100
100
N.A.
100
100
86.6
6.6
N.A.
86.6
N.A.
93.3
N.A.
P-Site Similarity:
100
N.A.
100
40
N.A.
100
100
N.A.
100
100
100
40
N.A.
93.3
N.A.
93.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
25.3
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
38.3
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
20
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
46.6
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
17
0
0
9
25
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
9
0
9
17
0
0
0
0
0
0
0
9
0
0
17
% D
% Glu:
0
0
67
9
9
0
0
0
0
0
0
0
0
9
75
% E
% Phe:
0
9
0
0
0
0
9
9
0
9
9
0
0
0
0
% F
% Gly:
9
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
75
9
0
0
9
0
0
9
0
0
0
0
% H
% Ile:
84
0
0
0
9
0
0
0
0
9
9
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
75
0
0
0
75
9
% K
% Leu:
0
9
0
0
0
0
9
0
0
0
0
59
0
0
0
% L
% Met:
0
59
0
0
0
9
0
0
0
0
0
25
0
0
0
% M
% Asn:
0
0
0
0
75
0
0
0
0
0
0
0
9
0
0
% N
% Pro:
0
0
0
0
0
9
0
0
92
0
0
0
9
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
9
0
0
0
0
0
9
9
0
9
0
9
0
% R
% Ser:
0
0
0
0
0
0
59
0
0
0
75
0
75
0
0
% S
% Thr:
0
17
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
9
0
0
0
75
0
0
0
0
0
0
0
9
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
9
0
0
% W
% Tyr:
0
0
0
0
0
0
0
84
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _